Effects of a Helicobacter pylori eradication regimen on anti-platelet autoantibody response in infected and uninfected patients with idiopathic thrombocytopenic purpura.
نویسندگان
چکیده
Thirty-seven patients with idiopathic thrombocytopenic purpura (ITP) were treated with a standard Helicobacter pylori eradication regimen irrespective of H. pylori infection. Our results indicate that platelet recovery results from the disappearance of H. pylori itself, and is mediated, in part, through suppression of anti-platelet autoantibody production.
منابع مشابه
Helicobacter pylori Eradication in Adult Patients with Acute Idiopathic Thrombocytopenic Purpura (ITP)
Background and Objective: Different studies have investigated the link between helicobacter pylori and extra digestive diseases such as idiopathic thrombocytopenic purpura. However, the relationship between ITP and H pylori is less clear. Most of the studies have focused on H pylori eradication in chronic ITP, so we focused on the effect of H pylori eradication on chronicity of ITP in adult pat...
متن کاملImpact of Helicobacter pylori Eradication Therapy on Platelet Counts in Patients With Chronic Idiopathic Thrombocytopenic Purpura
This study was a before and after clinical evaluation of Helicobacter pylori eradication on platelet counts in a group of 23 patients with chronic Idiopathic (Autoimmune) thrombocytopenic purpura (CITP). H. pylori infection was identified in patients by a (13)C-urea breath test and confirmed by an H. pylori stool antigen test. Eradication was conducted in patients testing positive. Infected (n ...
متن کاملRecovery of Thrombocytopenia after Eradica-tion of H. pylori Infection in Chronic Idiopathic Thrombocytopenic Purpura
Introduction: Recent studies have shown a relationship between H. pylori and chronic idiopathic thrombocytopenic purpura (CITP). Objective: The present study was performed to evaluate this relationship in Iranian patients. Methods: The antibody (IgG) against H. pylori was studied in sixty-two patients with CITP, comprising 25 males and 37 females (mean age: 30.38±12.23 yrs ) The patients posi...
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متن کاملHelicobacter pylori eradication can induce platelet recovery in idiopathic thrombocytopenic purpura.
Recent reports have suggested an association between Helicobacter pylori infection and idiopathic thrombocytopenic purpura (ITP). The prevalence of H pylori infection and the effect of its eradication in a series of 30 ITP patients were investigated. H pylori infection has been documented in 13 patients (43.33%) by 13C urea breath test and confirmed by histologic examination. Bacterium eradicat...
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ورودعنوان ژورنال:
- Haematologica
دوره 91 10 شماره
صفحات -
تاریخ انتشار 2006